Valsartan was formulated as oral-controlled release matrix tablets using hydrophilic polymer such as hydroxypropyl methyl cellulose K15M (HPMC K15M) along with natural gum such as Copal gum. In this work a new attempt was made for in situ interactions between drug and polymers were devised to control the release of poorly water soluble drugs from oral hydrophilic monolithic systems. Polymers such as HPMC K15M and natural gum such as Copal gum were used at different concentrations in various formulations, while drug was maintained constantly in all the formulations. These polymers were used to monitor matrix swelling and gel properties. These findings indicated that the swelling and gel formation in the presence of ionizable species within the hydrophilic matrices provide an attractive alternative for controlled drug delivery from a simple monolithic system.
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